Pregnancy and postpartum experiences induce transformative and lasting physiological changes in the maternal brain, yet the molecular mechanisms driving these persistent neural adaptations have remained unclear. This study utilizes brain-wide transcriptomic profiling to identify the dorsal hippocampal formation (dHF) as a primary site of transcriptional remodelling induced by reproductive experience. The researchers found that chronic postpartum stress disrupts these adaptations by altering dopamine dynamics and the dopamine-dependent histone modification, H3 dopaminylation, which mediates downstream changes in gene expression and behavior. By combining single-cell RNA sequencing, chemogenetics, and human brain tissue analysis, the study establishes dopamine as a central regulator of parity-induced neuroadaptations, revealing a fundamental mechanism by which the female brain is remodeled to sustain long-term behavioral changes.